Article

Elimination of reference mapping bias reveals robust immune related allele-specific expression in crossbred sheep

2019-04-25

Abstract excerpt

Pervasive allelic variation at both gene and single nucleotide level (SNV) between individuals is commonly associated with complex traits in humans and animals. Allele-specific expression (ASE) analysis, using RNA-Seq, can provide a detailed annotation of allelic imbalance and infer the existence of cis-acting transcriptional regulation. However, variant detection in RNA-Seq data is compromised by biased mapping o...

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Literature Corpus work: 01abe4ae-2879-5e2e-b9f3-475adc35b2d2
DOI: 10.1101/619122

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