Article
Normalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios.
BMC bioinformatics - 2 Oct 2008
Staaf Johan, Vallon-Christersson Johan, Lindgren David, Juliusson Gunnar, Rosenquist Richard, Höglund Mattias, Borg Ake, Ringnér Markus
Abstract excerpt
BACKGROUND: Illumina Infinium whole genome genotyping (WGG) arrays are increasingly being applied in cancer genomics to study gene copy number alterations and allele-specific aberrations such as loss-of-heterozygosity (LOH). Methods developed for normalization of WGG arrays have mostly focused on diploid, normal samples. However, for cancer samples genomic aberrations may confound normalization and data...
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