Article
Association of the HLA-B alleles with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in the Javanese and Sundanese population of Indonesia: the important role of the HLA-B75 serotype.
Pharmacogenomics - 1 Dec 2017
Yuliwulandari Rika, Kristin Erna, Prayuni Kinasih, Sachrowardi Qomariyah, Suyatna Franciscus D, Menaldi Sri Linuwih, Wichukchinda Nuanjun, Mahasirimongkol Surakameth, Cavallari Larisa H
Abstract excerpt
Carbamazepine (CBZ) is a common cause of life-threatening cutaneous adverse drug reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Previous studies have reported a strong association between the HLA genotype and CBZ-induced SJS/TEN. We investigated the association between the HLA genotype and CBZ-induced SJS/TEN in Javanese and Sundanese patients in Indonesia. Nine unrelated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.