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Article

Association study of polymorphisms in insulin induced gene 2 (INSIG2) with antipsychotic-induced weight gain in European and African-American schizophrenia patients.

Human psychopharmacology - 1 Apr 2010

Tiwari Arun K, Zai Clement C, Meltzer Herbert Y, Lieberman Jeffrey A, Müller Daniel J, Kennedy James L

Abstract excerpt

OBJECTIVE: Atypical antipsychotic drugs, in particular clozapine and olanzapine, influence cellular lipogenesis and are associated with metabolic side effects including weight gain. Insulin induced gene 2 (INSIG2) mediates feedback control of lipid synthesis and polymorphisms in the gene (rs17587100, rs10490624 and rs17047764) have been associated with antipsychotic induced weight gain. In this study we intended...

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Source

Identifiers

PMID: 20373477
DOI: 10.1002/hup.1111

Genes

INSIG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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