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Article

Variants of the mannose-binding lectin gene in the Benin population: heterozygosity for the p.G57E allele may confer a selective advantage. 2007.

Human biology - 1 Dec 2009

Dossou-Yovo Omer Placide, Lapoumeroulie Claudine, Hauchecorne Michelle, Zaccaria Isabelle, Ducrocq Rolande, Krishnamoorthy Rajagopal, Rahimy Mohamed Chérif, Elion Jacques

Abstract excerpt

Human mannose- binding lectin (MBL) plays an important role in innate immunity. MBL deficiency is associated with mutations in the promoter region and in exon 1 of the MBL2 gene. Such deficiency has been correlated with elevated incidence of infections in infancy and in immunocompromised adults....

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Source

Identifiers

PMID: 20504205
DOI: 10.3378/027.081.0630

Genes

MBL2
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20504205-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Variants of the mannose-binding lectin gene in the Benin population: heterozygosity for the p.G57E allele may confer a selective advantage. 2007.PMID 20504205Read ↗

Variants of the mannose-binding lectin gene in the Benin population: heterozygosity for the p.G57E allele may confer a selective advantage.Semantic proximity Read ↗

Mannose-binding lectin alleles in sub-Saharan Africans and relation with susceptibility to infections.Semantic proximity Read ↗

Mutations in the human mannose-binding protein gene: frequencies in several population groups.Semantic proximity Read ↗

Genetic polymorphism of the mannose-binding protein gene in children with sickle cell disease: identification of three new variant alleles and relationship to infections.Semantic proximity Read ↗

Sequence analysis of the mannose-binding lectin (MBL2) gene reveals a high degree of heterozygosity with evidence of selection.Semantic proximity Read ↗

An analysis of genetic variation across the MBL2 locus in Dutch Caucasians indicates that 3' haplotypes could modify circulating levels of mannose-binding lectin.Semantic proximity Read ↗

Association of a new mannose-binding lectin variant with severe malaria in Gabonese children.Semantic proximity Read ↗

Variant G57E of mannose binding lectin associated with protection against tuberculosis caused by Mycobacterium africanum but not by M. tuberculosis.Semantic proximity Read ↗

If there is an evolutionary selection pressure for the high frequency of MBL2 polymorphisms, what is it?Semantic proximity Read ↗

A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein.Semantic proximity Read ↗

Polymorphisms in mannose-binding lectin (MBL) gene and their association with MBL protein levels in serum in the Hu sheep.Semantic proximity Read ↗

Promoter variants of the human mannose-binding lectin gene show different binding.Semantic proximity Read ↗

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