Article
A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein.
Immunogenetics - 1 Jan 1994
Madsen H O, Garred P, Kurtzhals J A, Lamm L U, Ryder L P, Thiel S, Svejgaard A
Abstract excerpt
Human mannan-binding protein (MBP) is a serum lectin participating in the innate immune defence. Low MBP concentrations are explained by the dominant action of a point mutation at codon 54 of the MBP gene in Eskimos, partially in Caucasians, but not in Africans. A previously described point mutat...
Topics
- Alleles
- Asian People
- Base Sequence
- Black People
- Carrier Proteins
- Collectins
- Denmark
- Gene Frequency
- Genotype
- Greenland
- Humans
- Inuit
- Kenya
- Molecular Sequence Data
- Polymorphism, Genetic
- Sequence Homology, Nucleic Acid
- White People