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Article

Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age.

PLoS biology - 18 May 2010

Kauffman Amanda L, Ashraf Jasmine M, Corces-Zimmerman M Ryan, Landis Jessica N, Murphy Coleen T

Abstract excerpt

Of all the age-related declines, memory loss is one of the most devastating. While conditions that increase longevity have been identified, the effects of these longevity-promoting factors on learning and memory are unknown. Here we show that the C. elegans Insulin/IGF-1 receptor mutant daf-2 improves memory performance early in adulthood and maintains learning ability better with age but, surprisingly,...

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Identifiers

PMID: 20502519
DOI: 10.1371/journal.pbio.1000372
PMCID: PMC2872642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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