Article
A C. elegans Thermosensory Circuit Regulates Longevity through crh-1/CREB-Dependent flp-6 Neuropeptide Signaling.
Developmental cell - 24 Oct 2016
Chen Yen-Chih, Chen Hung-Jhen, Tseng Wei-Chin, Hsu Jiun-Min, Huang Tzu-Ting, Chen Chun-Hao, Pan Chun-Liang
Abstract excerpt
Sensory perception, including thermosensation, shapes longevity in diverse organisms, but longevity-modulating signals from the sensory neurons are largely obscure. Here we show that CRH-1/CREB activation by CMK-1/CaMKI in the AFD thermosensory neuron is a key mechanism that maintains lifespan at warm temperatures in C. elegans. In response to temperature rise and crh-1 activation, the AFD neurons produce and...
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