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Article

CBP-1 Acts in GABAergic Neurons to Double Life Span in Axenically Cultured Caenorhabditis elegans.

The journals of gerontology. Series A, Biological sciences and medical sciences - 12 Jul 2019

Cai Huaihan, Dhondt Ineke, Vandemeulebroucke Lieselot, Vlaeminck Caroline, Rasulova Madina, Braeckman Bart P

Abstract excerpt

When cultured in axenic medium, Caenorhabditis elegans shows the largest life-span extension compared with other dietary restriction regimens. However, the underlying molecular mechanism still remains elusive. The gene cbp-1, encoding the worm ortholog of p300/CBP (CREB-binding protein), is one of the very few key genes known to be essential for life span doubling under axenic dietary restriction (ADR). By using...

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Identifiers

PMID: 29099917
DOI: 10.1093/gerona/glx206
PMCID: PMC6625597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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