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Article

Aging-dependent and -independent modulation of associative learning behavior by insulin/insulin-like growth factor-1 signal in Caenorhabditis elegans.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Nov 2005

Murakami Hana, Bessinger Karalee, Hellmann Jason, Murakami Shin

Abstract excerpt

Mutations in the insulin/IGF-1 neuroendocrine pathway extend lifespan and affect development, metabolism, and other biological processes in Caenorhabditis elegans and in other species. In addition, they may play a role in learning and memory. Investigation of the insulin/IGF-1 pathway may provide clues for the prevention of age-related declines in cognitive functions. Here, we examined the effects of the...

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PMID: 16306402
DOI: 10.1523/JNEUROSCI.3600-04.2005
PMCID: PMC6725869

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