Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional Signatures

29 Jul 2015

Abstract excerpt

Calorie restriction (CR) enhances longevity and mitigates aging phenotypes in numerous species. Physiological responses to CR are cell-type specific and variable throughout the lifespan. However, the mosaic of molecular changes responsible for CR benefits remains unclear, particularly in brain regions susceptible to deterioration during aging. We examined the influence of long-term CR on the CA1 hippocampal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26221964
DOI: 10.1371/journal.pone.0133923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional SignaturesPMID 26221964Read ↗

Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and agingSemantic proximity Read ↗

Spatiotemporal profiling reveals the impact of caloric restriction on mammalian brain agingSemantic proximity Read ↗

Crtc1 Activates a Transcriptional Program Deregulated at Early Alzheimer's Disease-Related StagesSemantic proximity Read ↗

Changes in behavior and gene expression induced by caloric restriction in C57BL/6 miceSemantic proximity Read ↗

Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice.Semantic proximity Read ↗

Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age.Semantic proximity Read ↗

Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive ImpairmentSemantic proximity Read ↗

Temporal linkage between the phenotypic and genomic responses to caloric restriction.Semantic proximity Read ↗

A single-cell transcriptomic analysis of the mouse hippocampus after voluntary exerciseSemantic proximity Read ↗

Life-long Dietary Restrictions have Negligible or Damaging Effects on Late-life Cognitive Performance: A Key Role for Genetics in OutcomesSemantic proximity Read ↗

Molecular mechanisms of brain aging and neurodegenerative disorders: lessons from dietary restrictionSemantic proximity Read ↗

Molecular mechanisms of brain aging and neurodegenerative disorders: lessons from dietary restrictionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.