Article
Tau levels do not influence human ALS or motor neuron degeneration in the SOD1G93A mouse.
Neurology - 25 May 2010
Taes I, Goris A, Lemmens R, van Es M A, van den Berg L H, Chio A, Traynor B J, Birve A, Andersen P, Slowik A, Tomik B, Brown R H, Shaw C E, Al-Chalabi A, Boonen S, Van Den Bosch L, Dubois B, Van Damme P, Robberecht W
Abstract excerpt
BACKGROUND: The microtubule-associated protein tau is thought to play a pivotal role in neurodegeneration. Mutations in the tau coding gene MAPT are a cause of frontotemporal dementia, and the H1/H1 genotype of MAPT, giving rise to higher tau expression levels, is associated with progressive supranuclear palsy, corticobasal degeneration, and Parkinson disease (PD). Furthermore, tau hyperphosphorylation and...
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