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Article

Conserved role for autophagy in Rho1-mediated cortical remodeling and blood cell recruitment

24 May 2010

Abstract excerpt

Dynamic regulation of cell shape underlies many developmental and immune functions. Cortical remodeling is achieved under the central control of Rho GTPase pathways that modulate an exquisite balance in the dynamic assembly and disassembly of the cytoskeleton and focal adhesions. Macroautophagy (autophagy), associated with bulk cytoplasmic remodeling through lysosomal degradation, has clearly defined roles in...

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PMID: 20498061
DOI: 10.1073/pnas.0914168107

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