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Article

Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway.

Cardiovascular research - 1 Sept 2010

Horie Takahiro, Ono Koh, Nishi Hitoo, Nagao Kazuya, Kinoshita Minako, Watanabe Shin, Kuwabara Yasuhide, Nakashima Yasuhiro, Takanabe-Mori Rieko, Nishi Eiichiro, Hasegawa Koji, Kita Toru, Kimura Takeshi

Abstract excerpt

AIMS: A significant increase in congestive heart failure (CHF) was reported when the anti-ErbB2 antibody trastuzumab was used in combination with the chemotherapy drug doxorubicin (Dox). The aim of the present study was to investigate the role(s) of miRNAs in acute Dox-induced cardiotoxicity. METHODS AND RESULTS: Neuregulin-1-ErbB signalling is essential for maintaining adult cardiac function. We found a...

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Identifiers

PMID: 20495188
DOI: 10.1093/cvr/cvq148
PMCID: PMC2920811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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