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Article

Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity

20 Apr 2004

Abstract excerpt

In recent years, significant progress has been made in understanding cardiomyocyte differentiation. However, little is known about the regulation of myocyte survival despite the fact that myocyte apoptosis is a leading cause of heart failure. Here we report that transcription factor GATA-4 is a survival factor for differentiated, postnatal cardiomyocytes and an upstream activator of the antiapoptotic gene Bcl-X....

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PMID: 15100413
DOI: 10.1073/pnas.0401833101

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