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Article

Examining the protective role of ErbB2 modulation in human-induced pluripotent stem cell-derived cardiomyocytes.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Oct 2014

Eldridge Sandy, Guo Liang, Mussio Jodie, Furniss Mike, Hamre John, Davis Myrtle

Abstract excerpt

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are being used as an in vitro model system in cardiac biology and in drug discovery (e.g., cardiotoxicity testing). Qualification of these cells for use in mechanistic investigations will require detailed evaluations of cardiomyocyte signaling pathways and cellular responses. ErbB signaling and the ligand neuregulin play critical roles in...

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Source

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Identifiers

PMID: 25055963
DOI: 10.1093/toxsci/kfu150
PMCID: PMC4200050

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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