Article
TP53 and IDH2 Somatic Mutations Are Associated With Inferior Overall Survival After Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndrome.
Clinical lymphoma, myeloma & leukemia - 1 Nov 2017
Kharfan-Dabaja Mohamed A, Komrokji Rami S, Zhang Qing, Kumar Ambuj, Tsalatsanis Athanasios, Perkins Janelle, Nishihori Taiga, Field Teresa, Al Ali Najla, Mishra Asmita, Sallman David, Salem Karma Z, Zhang Ling, Moscinski Lynn, Fernandez Hugo F, Lancet Jeffrey, List Alan, Anasetti Claudio, Padron Eric
Abstract excerpt
BACKGROUND: Next-generation sequencing has identified somatic mutations that are prognostic of cancer. PATIENTS AND METHODS: We evaluated the incidence and prognostic significance of somatic mutations in 89 myelodysplastic syndrome (MDS) patients who received an allogeneic hematopoietic cell transplantation. Next-generation sequencing was performed on paraffin embedded bone marrow, which was obtained at a median...
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