Article
Influence of Mechanical Unloading on Articular Chondrocyte Dedifferentiation.
International journal of molecular sciences - 25 Apr 2018
Wuest Simon L, Caliò Martina, Wernas Timon, Tanner Samuel, Giger-Lange Christina, Wyss Fabienne, Ille Fabian, Gantenbein Benjamin, Egli Marcel
Abstract excerpt
Due to the limited self-repair capacity of articular cartilage, the surgical restoration of defective cartilage remains a major clinical challenge. The cell-based approach, which is known as autologous chondrocyte transplantation (ACT), has limited success, presumably because the chondrocytes acquire a fibroblast-like phenotype in monolayer culture. This unwanted dedifferentiation process is typically addressed...
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