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Tracking chondrocyte-to-fibroblast transformation via changes in cell electrophysiology

7 May 2025

Abstract excerpt

Cultured chondrocytes have potential for cartilage regeneration to treat degenerative diseases. However, when explanted chondrocytes are cultured in monolayer, they are known to dedifferentiate over time, adopting a more fibroblastic phenotype. This greatly impacts both research and potential clinical applications; cell-based cartilage repair therapies require significant in vitro expansion to obtain sufficient...

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PMID: 40335587
DOI: 10.1038/s41598-025-98958-1

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