Changes in lncRNA NORAD expression reflect stiffness-associated phenotypic alterations in human chondrocytes.

doi:10.1016/j.bbrc.2026.154418

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Article

Changes in lncRNA NORAD expression reflect stiffness-associated phenotypic alterations in human chondrocytes.

Biochemical and biophysical research communications - 24 Sept 2026

Lee Kyoung-Mi, Choi Seongyun, Yang Su-Eun, Yoon Dong Suk

Abstract excerpt

Extracellular matrix-derived mechanical signals play an important role in maintaining chondrocyte homeostasis, and their disruption has been implicated in osteoarthritis progression. Here, we investigated whether the long non-coding RNA NORAD reflects substrate stiffness-associated phenotypic alterations in human chondrocytes. Immortalized and primary human chondrocytes were cultured on substrates with defined...

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PMID: 42574948
DOI: 10.1016/j.bbrc.2026.154418

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