Strong synaptic transmission impact by copy number variations in schizophrenia.

doi:10.1073/pnas.1000274107

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Article

Strong synaptic transmission impact by copy number variations in schizophrenia.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 2010

Glessner Joseph T, Reilly Muredach P, Kim Cecilia E, Takahashi Nagahide, Albano Anthony, Hou Cuiping, Bradfield Jonathan P, Zhang Haitao, Sleiman Patrick M A, Flory James H, Imielinski Marcin, Frackelton Edward C, Chiavacci Rosetta, Thomas Kelly A, Garris Maria, Otieno Frederick G, Davidson Michael, Weiser Mark, Reichenberg Abraham, Davis Kenneth L, Friedman Joseph I, Cappola Thomas P, Margulies Kenneth B, Rader Daniel J, Grant Struan F A, Buxbaum Joseph D, Gur Raquel E, Hakonarson Hakon

Abstract excerpt

Schizophrenia is a psychiatric disorder with onset in late adolescence and unclear etiology characterized by both positive and negative symptoms, as well as cognitive deficits. To identify copy number variations (CNVs) that increase the risk of schizophrenia, we performed a whole-genome CNV analysis on a cohort of 977 schizophrenia cases and 2,000 healthy adults of European ancestry who were genotyped with 1.7...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20489179
DOI: 10.1073/pnas.1000274107
PMCID: PMC2890845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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