Article
Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission.
Blood - 19 Aug 2010
Nibourel Olivier, Kosmider Olivier, Cheok Meyling, Boissel Nicolas, Renneville Aline, Philippe Nathalie, Dombret Hervé, Dreyfus François, Quesnel Bruno, Geffroy Sandrine, Quentin Samuel, Roche-Lestienne Catherine, Cayuela Jean-Michel, Roumier Christophe, Fenaux Pierre, Vainchenker William, Bernard Olivier A, Soulier Jean, Fontenay Michaëla, Preudhomme Claude
Abstract excerpt
Mutations of the ten eleven translocation 2 gene (TET2) have recently been reported in myelodysplastic syndrome and myeloproliferative neoplasms. We analyzed the incidence and prognostic value of TET2 point mutations and other genomic alterations by direct sequencing and single nucleotide polymorphism microarray analysis in 111 de novo acute myeloid leukemia, who had all achieved complete remission (CR)....
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