Article
Modeling the therapeutic efficacy of p53 restoration in tumors.
Cell - 29 Dec 2006
Martins Carla P, Brown-Swigart Lamorna, Evan Gerard I
Abstract excerpt
Although restoration of p53 function is an attractive tumor-specific therapeutic strategy, it remains unclear whether p53 loss is required only for transition through early bottlenecks in tumorigenesis or also for maintenance of established tumors. To explore the efficacy of p53 reinstatement as a tumor therapy, we used a reversibly switchable p53 knockin (KI) mouse model that permits modulation of p53 status...
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