Article
The pathogen recognition receptor NOD2 regulates human FOXP3+ T cell survival.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2010
Rahman Meher K, Midtling Emilie H, Svingen Phyllis A, Xiong Yuning, Bell Michael P, Tung Jeanne, Smyrk Tom, Egan Larry J, Faubion William A
Abstract excerpt
The expression of pathogen recognition receptors in human FOXP3+ T regulatory cells is established, yet the function of these receptors is currently obscure. In the process of studying the function of both peripheral and lamina propria FOXP3+ lymphocytes in patients with the human inflammatory bowel disease Crohn's disease, we observed a clear deficiency in the quantity of FOXP3+ lymphocytes in patients with...
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