Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of TCR reactivity and HLA phenotype on naive CD8 T cell frequency in humans.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2010

Legoux François, Debeaupuis Emilie, Echasserieau Klara, De La Salle Henri, Saulquin Xavier, Bonneville Marc

Abstract excerpt

The impact of MHC phenotype on the shaping of the peripheral naive T cell repertoire in humans remains unknown. To address this, we compared the frequency and antigenic avidity of naive T cells specific for immunodominant self-, viral, and tumor Ags presented by a human MHC class I allele (HLA-A*02, referred to as A2) in individuals expressing or not this allele. Naive T cell frequencies varied from one Ag...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen Presentation
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Separation

Share to HLA-A Antigens

Share to HLA-A2 Antigen

Share to Lymphocyte Activation

Share to Lymphocyte Count

Share to Receptors, Antigen, T-Cell

Source

Identifiers

PMID: 20483723
DOI: 10.4049/jimmunol.1000295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of TCR reactivity and HLA phenotype on naive CD8 T cell frequency in humans.PMID 20483723Read ↗

TCR affinity and specificity requirements for human regulatory T-cell functionSemantic proximity Read ↗

A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population.Semantic proximity Read ↗

High-frequency and adaptive-like dynamics of human CD1 self-reactive T cells.Semantic proximity Read ↗

Quantifying size and diversity of the human T cell alloresponseSemantic proximity Read ↗

A predisposing effect of HLA class II genes in celiac disease by skewing the naive CD4+ T cell receptor repertoire.Semantic proximity Read ↗

Donor Unrestricted T Cells: A Shared Human T Cell ResponseSemantic proximity Read ↗

A comparative study of HLA binding affinity and ligand diversity: implications for generating immunodominant CD8+ T cell responses.Semantic proximity Read ↗

A predisposing effect of HLA class II genes in celiac disease by skewing the naïve CD4 <sup>+</sup> T-cell receptor repertoireSemantic proximity Read ↗

Comprehensive Analysis of CD4+ T Cell Response Cross-Reactive to SARS-CoV-2 Antigens at the Single Allele Level of HLA Class II.Semantic proximity Read ↗

Functional and biological implications of clonotypic diversity among human donor-unrestricted T cells.Semantic proximity Read ↗

CD11b+CD28-CD4+ human T cells: activation requirements and association with HLA-DR alleles.Semantic proximity Read ↗

HLA-DRB1 molecules and antigenic experience shape the repertoire of CD4 T cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.