Article
Association study of the IL18RAP locus in three European populations with coeliac disease.
Human molecular genetics - 15 Mar 2009
Koskinen Lotta L E, Einarsdottir Elisabet, Dukes Emma, Heap Graham A R, Dubois Patrick, Korponay-Szabo Ilma R, Kaukinen Katri, Kurppa Kalle, Ziberna Fabiana, Vatta Serena, Not Tarcisio, Ventura Alessandro, Sistonen Pertti, Adány Róza, Pocsai Zsuzsa, Széles György, Mäki Markku, Kere Juha, Wijmenga Cisca, van Heel David A, Saavalainen Päivi
Abstract excerpt
Coeliac disease is caused by dietary gluten, triggering a chronic inflammation of the small intestine in genetically predisposed individuals. Recently, a risk locus on chromosome 2q11-q12, harbouring interleukin 18 receptor accessory protein (IL18RAP) and three other genes, was suggested for coeliac disease. IL18 has been shown to play an important role in T helper type 1 activity in coeliac disease, making this...
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