Article
The Association of Polymorphisms in Genes Encoding Antioxidant Enzymes GPX1 (rs1050450), SOD2 (rs4880) and Transcriptional Factor Nrf2 (rs6721961) with the Risk and Development of Prostate Cancer.
Medicina (Kaunas, Lithuania) - 9 Oct 2022
Djokic Milica, Radic Tanja, Santric Veljko, Dragicevic Dejan, Suvakov Sonja, Mihailovic Smiljana, Stankovic Vesna, Cekerevac Milica, Simic Tatjana, Nikitovic Marina, Coric Vesna
Abstract excerpt
Background and Objectives: Mounting evidence implicates oxidative damage in prostate carcinogenesis, contributing to modifications of macromolecules that drive cellular malignant transformation. Functional single-nucleotide polymorphisms (SNPs) of enzymes involved in redox homeostasis can disrupt pro-oxidant-antioxidant balance, leading to accumulation of reactive oxygen species and oxidative damage. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.