Article
The LRRK2 R1441C mutation is more frequent than G2019S in Parkinson's disease patients from southern Italy.
Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2011
Criscuolo Chiara, De Rosa Anna, Guacci Anna, Simons Erik J, Breedveld Guido J, Peluso Silvio, Volpe Giampiero, Filla Alessandro, Oostra Ben A, Bonifati Vincenzo, De Michele Giuseppe
Abstract excerpt
BACKGROUND: Mutations in the leucine-rich repeat kinase 2 gene are the most frequent cause of familial and sporadic Parkinson's disease, and G2019S is the most common leucine-rich repeat kinase 2 mutation across several Mediterranean countries. METHODS: One hundred ninety-two patients with Parkinson's disease from Campania, a region in southern Italy, were screened for R1441C/H/G and G2019S by direct sequencing...
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