Article
Genetic screening for the LRRK2 R1441C and G2019S mutations in Parkinsonian patients from Campania.
Journal of Parkinson's disease - 1 Jan 2014
De Rosa Anna, De Michele Giuseppe, Guacci Anna, Carbone Rosa, Lieto Maria, Peluso Silvio, Picillo Marina, Barone Paolo, Salemi Fabrizio, Laiso Antonio, Saccà Francesco, Tessitore Alessandro, Pellecchia Maria Teresa, Bonifati Vincenzo, Criscuolo Chiara
Abstract excerpt
BACKGROUND: PARK8 is the most common known mendelian form of Parkinson's Disease (PD). It is due to mutations in the leucine-rich repeat kinase 2 (LRRK2) gene and G2019S is considered the most frequent mutation in the Caucasian population, in particular in the Southern Europe and Mediterranean co...
Topics
- Aged
- Female
- Genetic Testing
- Humans
- Italy
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged
- Mutation
- Parkinson Disease
- Protein Serine-Threonine Kinases