Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic screening for the LRRK2 R1441C and G2019S mutations in Parkinsonian patients from Campania.

Journal of Parkinson's disease - 1 Jan 2014

De Rosa Anna, De Michele Giuseppe, Guacci Anna, Carbone Rosa, Lieto Maria, Peluso Silvio, Picillo Marina, Barone Paolo, Salemi Fabrizio, Laiso Antonio, Saccà Francesco, Tessitore Alessandro, Pellecchia Maria Teresa, Bonifati Vincenzo, Criscuolo Chiara

Abstract excerpt

BACKGROUND: PARK8 is the most common known mendelian form of Parkinson's Disease (PD). It is due to mutations in the leucine-rich repeat kinase 2 (LRRK2) gene and G2019S is considered the most frequent mutation in the Caucasian population, in particular in the Southern Europe and Mediterranean countries. OBJECTIVE: We assessed the frequency of the G2019S and R1441C/H/G mutations in 513 (311 M and 202 F) unrelated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Genetic Testing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Mutation

Share to Parkinson Disease

Share to Protein Serine-Threonine Kinases

Source

Identifiers

PMID: 24496098
DOI: 10.3233/JPD-130312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic screening for the LRRK2 R1441C and G2019S mutations in Parkinsonian patients from Campania.PMID 24496098Read ↗

The LRRK2 R1441C mutation is more frequent than G2019S in Parkinson's disease patients from southern Italy.Semantic proximity Read ↗

Genetic screening for LRRK2 gene G2019S mutation in Parkinson's disease patients from Southern Italy.Semantic proximity Read ↗

Genetic analysis for five LRRK2 mutations in a Sardinian parkinsonian population: importance of G2019S and R1441C mutations in sporadic Parkinson's disease patients.Semantic proximity Read ↗

The prevalence of the G2019S and R1441C/G/H mutations in LRRK2 in German patients with Parkinson's disease.Semantic proximity Read ↗

High prevalence of LRRK2 mutations in familial and sporadic Parkinson's disease in Portugal.Semantic proximity Read ↗

Prevalence and clinical features of LRRK2 mutations in patients with Parkinson's disease in southern Spain.Semantic proximity Read ↗

LRRK2 G2019S is a common mutation in Spanish patients with late-onset Parkinson's disease.Semantic proximity Read ↗

Is the G2019S LRRK2 mutation common in all southern European populations?Semantic proximity Read ↗

[Genetic screening for the LRRK2, G2019S and R1441 codon mutations in Parkinson's disease patients from Extremadura, Spain].Semantic proximity Read ↗

No evidence for the LRRK2 p.L1795F variant in a Southern Italian cohort with Parkinson's disease.Semantic proximity Read ↗

Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain.Semantic proximity Read ↗

Frequency and phenotypes of LRRK2 G2019S mutation in Italian patients with Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.