Article
Synthetic effects of secG and secY2 mutations on exoproteome biogenesis in Staphylococcus aureus.
Journal of bacteriology - 1 Jul 2010
Sibbald Mark J J B, Winter Theresa, van der Kooi-Pol Magdalena M, Buist G, Tsompanidou E, Bosma Tjibbe, Schäfer Tina, Ohlsen Knut, Hecker Michael, Antelmann Haike, Engelmann Susanne, van Dijl Jan Maarten
Abstract excerpt
The gram-positive pathogen Staphylococcus aureus secretes various proteins into its extracellular milieu. Bioinformatics analyses have indicated that most of these proteins are directed to the canonical Sec pathway, which consists of the translocation motor SecA and a membrane-embedded channel composed of the SecY, SecE, and SecG proteins. In addition, S. aureus contains an accessory Sec2 pathway involving the...
Topics
- Animals
- Bacterial Proteins
- Gene Expression Profiling
- Gene Expression Regulation, Bacterial
- Mice
- Mutation
- Staphylococcal Infections
- Staphylococcus aureus
- Transcription, Genetic
- Virulence