Article
Catabolic effects of continuous human PTH (1--38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation.
Endocrinology - 1 Sept 2001
Ma Y L, Cain R L, Halladay D L, Yang X, Zeng Q, Miles R R, Chandrasekhar S, Martin T J, Onyia J E
Abstract excerpt
Continuous infusion of PTH in vivo results in active bone resorption. To investigate the molecular basis of the catabolic effect of PTH in vivo, we evaluated the role of OPG and RANKL, which are known to influence osteoclast formation and function. Weanling rats fed a calcium-free diet were parathyroidectomized and infused with PTH via an Alzet pump to examine: 1) the changes of serum-ionized calcium and...
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