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Article

The siRNA targeted to mdr1b and mdr1a mRNAs in vivo sensitizes murine lymphosarcoma to chemotherapy.

BMC cancer - 14 May 2010

Patutina Olga A, Mironova Nadezda L, Popova Nelly A, Kaledin Vasily I, Nikolin Valery P, Vlassov Valentin V, Zenkova Marina A

Abstract excerpt

BACKGROUND: One of the main obstacles for successful cancer polychemotherapy is multiple drug resistance phenotype (MDR) acquired by tumor cells. Currently, RNA interference represents a perspective strategy to overcome MDR via silencing the genes involved in development of this deleterious phenotype (genes of ABC transporters, antiapoptotic genes, etc.). METHODS: In this study, we used the siRNAs targeted to...

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Share to Antineoplastic Agents, Alkylating
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclophosphamide

Share to Genetic Therapy

Share to Lymphoma, Non-Hodgkin

Share to Mice, Inbred CBA

Share to RNA, Small Interfering

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Source

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Identifiers

PMID: 20470373
DOI: 10.1186/1471-2407-10-204
PMCID: PMC2886043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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