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Article

Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi).

FEBS letters - 19 Jun 2003

Nieth Christiane, Priebsch Axel, Stege Alexandra, Lage Hermann

Abstract excerpt

For reversal of MDR1 gene-dependent multidrug resistance (MDR), two small interfering RNA (siRNA) constructs were designed to inhibit MDR1 expression by RNA interference. SiRNA duplexes were used to treat human pancreatic carcinoma (EPP85-181RDB) and gastric carcinoma (EPG85-257RDB) cells. In both cellular systems, siRNAs could specifically inhibit MDR1 expression up to 91% at the mRNA and protein levels....

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Identifiers

PMID: 12804765
DOI: 10.1016/s0014-5793(03)00523-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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