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Article

Reversing multidrug resistance by RNA interference through the suppression of MDR1 gene in human hepatoma cells.

World journal of gastroenterology - 7 Jun 2006

Chen Xiao-Ping, Wang Qi, Guan Jian, Huang Zhi-Yong, Zhang Wan-Guang, Zhang Bi-Xiang

Abstract excerpt

AIM: To reverse the multidrug resistance (MDR) by RNA interference (RNAi)-mediated MDR1 suppression in hepatoma cells. METHODS: For reversing MDR by RNAi technology, two different short hairpin RNAs (shRNAs) were designed and constructed into pGenSil-1 plasmid, respectively. They were then transf...

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Share to Antibiotics, Antineoplastic
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular

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Share to Drug Resistance, Multiple

Share to Genes, MDR

Share to RNA, Small Interfering

Share to Suppression, Genetic

Source

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Identifiers

PMID: 16733848
DOI: 10.3748/wjg.v12.i21.3332
PMCID: PMC4087887

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ADM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16733848-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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