Article
Chromosome copy number changes carry prognostic information independent of KIT/PDGFRA point mutations in gastrointestinal stromal tumors.
BMC medicine - 14 May 2010
Silva Mara, Veiga Isabel, Ribeiro Franclim R, Vieira Joana, Pinto Carla, Pinheiro Manuela, Mesquita Bárbara, Santos Catarina, Soares Marta, Dinis José, Santos Lúcio, Lopes Paula, Afonso Mariana, Lopes Carlos, Teixeira Manuel R
Abstract excerpt
BACKGROUND: Oncogenic point mutations in KIT or PDGFRA are recognized as the primary events responsible for the pathogenesis of most gastrointestinal stromal tumors (GIST), but additional genomic alterations are frequent and presumably required for tumor progression. The relative contribution of such alterations for the biology and clinical behavior of GIST, however, remains elusive. METHODS: In the present...
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