Article
Cytogenetic and molecular analyses of 291 gastrointestinal stromal tumors: site-specific cytogenetic evolution as evidence of pathogenetic heterogeneity.
Oncotarget - 1 Jan 2022
Gorunova Ludmila, Boye Kjetil, Panagopoulos Ioannis, Berner Jeanne-Marie, Bjerkehagen Bodil, Hompland Ivar, Lobmaier Ingvild, Hølmebakk Toto, Hveem Tarjei S, Heim Sverre, Micci Francesca
Abstract excerpt
Gastrointestinal stromal tumor (GIST) is a mesenchymal neoplasm with variable behavior. An increased understanding of the tumor pathogenesis may improve clinical decision-making. Our aim was to obtain more data about the overall chromosome aberrations and intratumor cytogenetic heterogeneity in GIST. We analyzed 306 GIST samples from 291 patients using G-banding, direct sequencing, and statistics. Clonal...
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