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Article

c-Kit/PDGFRA gene status alterations possibly related to primary imatinib resistance in gastrointestinal stromal tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2007

Miselli Francesca C, Casieri Paola, Negri Tiziana, Orsenigo Marta, Lagonigro M Stefania, Gronchi Alessandro, Fiore Marco, Casali Paolo G, Bertulli Rossella, Carbone Antonino, Pierotti Marco A, Tamborini Elena, Pilotti Silvana

Abstract excerpt

PURPOSE: To correlate morphologic changes with molecular, biochemical, and cytogenetic profiles in gastrointestinal stromal tumor (GIST) patients before and after imatinib treatment. EXPERIMENTAL DESIGN: We investigated 132 tumor samples obtained from 35 patients with advanced disease who underwent resective surgery after imatinib treatment according to the European Organization for Research and Treatment of...

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Identifiers

PMID: 17438095
DOI: 10.1158/1078-0432.CCR-06-1745

Genes

PDGFRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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