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Article

Cancer-Specific Functions of SIRT1 Enable Human Epithelial Cancer Cell Growth and Survival

15 Nov 2005

Abstract excerpt

SIRT1 is a conserved NAD-dependent deacetylase that regulates life span in accord with nutritional provision. In mammalian cells, SIRT1 also down-regulates stress-induced p53 and FoxO pathways for apoptosis, thus favoring survival under stress. The functioning of SIRT1 under normal, nonstressed conditions of cell growth is unknown. Here we have asked if SIRT1 has the capacity to influence cell viability in the...

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PMID: 16288037
DOI: 10.1158/0008-5472.can-05-1923

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