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Article

Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells

15 May 2009

Abstract excerpt

Prostate cancer (PCa), next only to skin cancer, is the most commonly occurring malignancy in men in the US. Aging is recognized as a major risk factor for this neoplasm as a man's chance for developing this disease significantly increases with increasing age. Because aging is inevitable, Americans are living longer, and the existing treatments have not been able to manage this neoplasm, novel mechanism-based...

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PMID: 19377286
DOI: 10.4161/cc.8.10.8408

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