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Article

Functional, proteomic and phenotypic in vitro studies evidence podocyte injury after chronic exposure to heparin.

Toxicology and applied pharmacology - 15 Oct 2021

Delézay Olivier, Hodin Sophie, Hé Zhiguo, Ollier Edouard, Delavenne Xavier

Abstract excerpt

Unfractionated heparin (UFH) is a widely used anticoagulant that possess numerous properties including anti-inflammatory, anti-viral, anti-angiogenesis, and anti-metastatic effects. The effect of this drug was evaluated on the podocyte, an important actor of the glomerular filtration. Using a functional approach, we demonstrate that heparin treatment leads to a functional podocyte perturbation characterized by...

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Identifiers

PMID: 34411582
DOI: 10.1016/j.taap.2021.115683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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