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Article

Fibroblast growth factor-specific modulation of cellular response by syndecan-4.

The Journal of cell biology - 13 May 2002

Horowitz Arie, Tkachenko Eugene, Simons Michael

Abstract excerpt

Proteoglycans participate in growth factor interaction with the cell surface through their heparan sulfate chains (HS), but it is not known if they are otherwise involved in growth factor signaling. It appears now that the syndecan-4 core protein, a transmembrane proteoglycan shown previously to bind phosphatidylinositol 4,5-bisphosphate (PIP(2)) and activate PKC alpha, participates in mediating the effects of...

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Source

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Identifiers

PMID: 12011116
DOI: 10.1083/jcb.200112145
PMCID: PMC2173870

Genes

PIP
FGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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