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Article

Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities

11 May 2010

Abstract excerpt

Phenotypic heterogeneity has been widely observed in cellular populations. However, the extent to which heterogeneity contains biologically or clinically important information is not well understood. Here, we investigated whether patterns of basal signaling heterogeneity, in untreated cancer cell populations, could distinguish cellular populations with different drug sensitivities. We modeled cellular...

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PMID: 20461076
DOI: 10.1038/msb.2010.22

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