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Article

A quantitative analysis of the interplay of environment, neighborhood, and cell state in 3D spheroids.

Molecular systems biology - 1 Dec 2020

Zanotelli Vito Rt, Leutenegger Matthias, Lun Xiao-Kang, Georgi Fanny, de Souza Natalie, Bodenmiller Bernd

Abstract excerpt

Cells react to their microenvironment by integrating external stimuli into phenotypic decisions via an intracellular signaling network. To analyze the interplay of environment, local neighborhood, and internal cell state effects on phenotypic variability, we developed an experimental approach that enables multiplexed mass cytometric imaging analysis of up to 240 pooled spheroid microtissues. We quantified the...

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Identifiers

PMID: 33369114
DOI: 10.15252/msb.20209798
PMCID: PMC7765047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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