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Article

Longitudinal analysis of the behavioural phenotype in YAC128 (C57BL/6J) Huntington's disease transgenic mice.

Brain research bulletin - 1 Jun 2012

Brooks Simon, Higgs Gemma, Janghra Nari, Jones Lesley, Dunnett Stephen B

Abstract excerpt

To determine the suitability of mouse models of disease for therapeutic trials, the models must be characterised to determine their similarity to the human condition, and utility for specific therapeutic approaches. The YAC128 mouse model of HD has been bred on to C57BL/6J background in order to provide a mouse model of the disease better suited to behavioural testing, than the visually impaired original line on...

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Source

Identifiers

PMID: 20460143
DOI: 10.1016/j.brainresbull.2010.05.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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