Article
Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes.
BMC medical genetics - 6 May 2010
Boraska Vesna, Rayner Nigel W, Groves Christopher J, Frayling Timothy M, Diakite Mahamadou, Rockett Kirk A, Kwiatkowski Dominic P, Day-Williams Aaron G, McCarthy Mark I, Zeggini Eleftheria
Abstract excerpt
BACKGROUND: The TNF/LTA locus has been a long-standing T2D candidate gene. Several studies have examined association of TNF/LTA SNPs with T2D but the majority have been small-scale and produced no convincing evidence of association. The purpose of this study is to examine T2D association of tag SNPs in the TNF/LTA region capturing the majority of common variation in a large-scale sample set of UK/Irish origin....
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