Article
Tumor necrosis factor-alpha allele 2 shows an association with insulin-dependent diabetes mellitus in Latvians.
Annals of the New York Academy of Sciences - 1 Apr 2002
Shtauvere-Brameus A, Dabadghao P, Rumba I, Sanjeevi C B
Abstract excerpt
Insulin-dependent diabetes mellitus (IDDM) is one of the most common chronic diseases. It is an autoimmune disease. Genes contributing the most for development of IDDM are located on chromosome 6p21.3 in the region called the major histocompatibility complex (MHC). HLA-DQ8/DR4 and DQ2/DR3 have shown positive association with IDDM, while DQ6 has negative association with IDDM in most Caucasian populations. The...
Topics
- Adolescent
- Alleles
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Histocompatibility Antigens Class I
- Humans
- Infant
- Infant, Newborn
- Latvia
- Male
- Microsatellite Repeats
- Polymerase Chain Reaction
- Tumor Necrosis Factor-alpha