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Article

Obesity-dependent association of TNF-LTA locus with type 2 diabetes in North Indians.

Journal of molecular medicine (Berlin, Germany) - 1 May 2010

Mahajan Anubha, Tabassum Rubina, Chavali Sreenivas, Dwivedi Om Prakash, Chauhan Ganesh, Tandon Nikhil, Bharadwaj Dwaipayan

Abstract excerpt

Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in the TNF-LTA locus encoding the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha have been shown to be associated with various metabolic traits including susceptibility to type 2 diabetes, metabolic syndrome, insulin resistance, and increased body mass index (BMI) in...

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Topics

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Diabetes Mellitus, Type 2
Genetic Loci
India
Lymphotoxin-alpha
Obesity
Promoter Regions, Genetic
Tumor Necrosis Factor-alpha
White People

Source

Identifiers

PMID: 20177654
DOI: 10.1007/s00109-010-0594-5

Genes

TNF
LTA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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