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Article

Abnormal genetic and epigenetic changes in signal transducer and activator of transcription 4 in the pathogenesis of inflammatory bowel diseases.

Digestive diseases and sciences - 1 Oct 2012

Kim Seung Won, Kim Eun Soo, Moon Chang Mo, Kim Tae Il, Kim Won Ho, Cheon Jae Hee

Abstract excerpt

BACKGROUND AND AIMS: Changes in the expression of signal transducer and activator of transcription 4 (STAT4) contribute to the development of a variety of autoimmune diseases including inflammatory bowel diseases (IBDs). Moreover, epigenetic modifications, including DNA methylation, are considered a basis for differentiation of T helper cells and regulation of cytokines. In this study, we investigated the...

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Source

Identifiers

PMID: 22569826
DOI: 10.1007/s10620-012-2199-z

Genes

STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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