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Article

STAT4 gene influences genetic predisposition to ulcerative colitis but not Crohn's disease in the Spanish population: a replication study.

Human immunology - 1 May 2010

Diaz-Gallo Lina Marcela, Palomino-Morales Rogelio J, Gómez-García María, Cardeña Carlos, Rodrigo Luis, Nieto Antonio, Alcain Guillermo, Cueto Ignacio, López-Nevot Miguel A, Martin Javier

Abstract excerpt

Recently, the signal transducer and activator of transcription 4 (STAT4) gene has been associated with multiple autoimmune diseases. Interestingly, a recent work showed that the T allele of the rs7574865 STAT4 SNP was associated with inflammatory bowel disease (IBD) in a Spanish population. The aim of the present study was to reevaluate the role of the STAT4 rs7574865 polymorphism on IBD. The present case-control...

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Source

Identifiers

PMID: 20153791
DOI: 10.1016/j.humimm.2010.02.005

Genes

STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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STAT4 gene influences genetic predisposition to ulcerative colitis but not Crohn's disease in the Spanish population: a replication study.PMID 20153791Read ↗

Association of STAT4 rs7574865 polymorphism with susceptibility to inflammatory bowel disease: A systematic review and meta-analysis.Semantic proximity Read ↗

Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease.Semantic proximity Read ↗

Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.Semantic proximity Read ↗

Associations between STAT3 rs744166 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: a meta-analysis.Semantic proximity Read ↗

Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases.Semantic proximity Read ↗

Abnormal genetic and epigenetic changes in signal transducer and activator of transcription 4 in the pathogenesis of inflammatory bowel diseases.Semantic proximity Read ↗

Association of STAT4 rs7574865 polymorphism with autoimmune diseases: a meta-analysis.Semantic proximity Read ↗

Association between STAT3 gene polymorphisms and Crohn's disease susceptibility: a case-control study in a Chinese Han population.Semantic proximity Read ↗

Association between STAT3 gene polymorphisms and ulcerative colitis susceptibility: a case-control study in the Chinese Han population.Semantic proximity Read ↗

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Association of STAT4 with rheumatoid arthritis: a replication study in three European populations.Semantic proximity Read ↗

STAT4 single nucleotide gene polymorphisms and susceptibility to endometriosis-related infertility.Semantic proximity Read ↗

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