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Article

Trophic Activity of Human P2X7 Receptor Isoforms A and B in Osteosarcoma

16 Sept 2014

Abstract excerpt

The P2X7 receptor (P2X7R) is attracting increasing attention for its involvement in cancer. Several recent studies have shown a crucial role of P2X7R in tumour cell growth, angiogenesis and invasiveness. In this study, we investigated the role of the two known human P2X7R functional splice variants, the full length P2X7RA and the truncated P2X7RB, in osteosarcoma cell growth. Immunohistochemical analysis of a...

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PMID: 25226385
DOI: 10.1371/journal.pone.0107224

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